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Robert

Reply:

Robert,

Thanks. You brought up a lot of aspects I wasn’t aware of.

Regarding language, I did notice in the Ukraine (where people grow up speaking both Ukrainian and Russian) people seemed to pick up further languages easier, so that would lend some anecdotal evidence to your point.

– Greg

[]

Rasul Sha'ir permalink
June 24, 2010

Great post Greg,

With respect to the research showing that it takes about 10 years to become an “expert” in a field. I always am of the mind of what does that exactly mean. . .an “expert” (I’d much prefer discussion about having expertise than being an expert). I think anyone will agree that the more you learn the less you know. So being an expert is relative. You might be an expert compared to Joe Blow but are you an expert compared to Einstein?

What I strongly believe is that interdisciplinary is a heavy word should be looked at more in the sense of the spirit of the word vs. its literally meaning. Particularly in business (the academic world is an entirely different beast as the conversations of Einat and Robert speak more to). Interdisciplinary thinking for me means being aware of the broad array of dynamics at play that influence and determines customer behavior. I emphasize “being aware” because simply being aware of the existence of something that someone else is not aware of, puts you leaps and bounds ahead of others (you don’t even have to understand it entirely. . .just be aware of it).

Have you ever read the Medici Affect by Frans Johansson? If you have then I need not go further. If you haven’t. . .I highly recommend reading it. He talks EXACTLY about your theme of synthesis and how innovation is powerful at the intersection of disciplines (but from a business perspective). In my top 10 of fave business books.

Reply:

Rasul,

Nice to see you again. Yes, I read the Medici Effect, but some years ago. I’ll take another look.

Btw. The 10 years rule comes from research by Anders Ericsson and was based on world class performers (and it wasn’t any experience, but “deliberate practice”).

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(a bit more in depth).

– Greg

[]

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permalink
November 6, 2010

This article was personally uplifting to me, as I have been personally exploring various inter disciplinary fields to gain new insights. I think its becoming more of a necessity as we are moving towards an interconnected world. This perspective of synthesizing disparate ideas reminds me of Geoffrey Chew’s Bootstrap hypothesis in Physics which states that nature cannot be reduced to fundamental building blocks, but through mutually consistent relationships, thus setting the ground for quantum aspects of matter. I am big fan of Quantum physics and I think some of its fundamental ideas about perception can give us amazing insights about this connected age. I think we need this bootstrap approach to management where several divergent fields are integrated to arrive at an networked mosaic of ideas and concepts.

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Amanita phalloides, commonly known as the death cap, poisonous mushroom in the forest.
Amanita phalloides, commonly known as the death cap, poisonous mushroom in the forest.

The death-cap mushroom has a long history as a tool of murder and suicide, going back to ancient Roman times. The fungus, Amanita phalloides , produces one of the world's deadliest toxins: α -amanitin. While it may seem ill-advised, researchers are eager to synthesize the toxin because studies have shown that it could help fight cancer. Scientists now report in the Journal of the American Chemical Society how they overcame obstacles to synthesize the death-cap killer compound.

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-Amanitin achieves its impressive deadliness by acting as a potent inhibitor of RNA polymerase II, the enzyme primarily responsible for transcribing genes into the messenger molecule RNA. Using -amanitin bound to antibodies against tumor molecules, cancer researchers have reportedly cured mice of pancreatic cancer. These conjugates are currently in human trials; however, the only way to obtain -amanitin so far has been to harvest mushrooms, which is time-consuming and results in relatively small amounts of the compound. Synthetic production approaches have been hampered by -amanitin's unusual bicyclic structure, among other tricky features. David M. Perrin and colleagues decided to take on the challenge to produce the toxin in the laboratory, once and for all.

The researchers had to work through three key obstacles to produce -amanitin in the laboratory: production of the "oxidatively delicate" 6-hydroxy-tryptathionine, the an enantio- selective synthesis of (2,3,4)-4,5-dihydroxy-isoleucine and a diastereoselective sulfoxidation to favor the ()-sulfoxide. Due to its toxic nature, the researchers limited production to less than a milligram, but based on their results, they are confident that good yields are can be readily obtained by scaling up the process. The researchers also say that the development of this synthetic route will enable chemists to attenuate the toxicity and potentially improve -amanitin's activity against cancer, something that is only made possible by the use of synthetic derivatives.

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Journal Reference :

Synthesis of the Death-Cap Mushroom Toxin α-Amanitin
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Wednesday, February 7 - Thursday, April 5, 2018

ANIMATED SHORTS EstimatedRun-Time: 83 min.

Dear Basketball – Glen Keane and Kobe Bryant, USA, 5min. Negative Space – Max Porter and Ru Kuwahata, France, 5min. Lou – Dave Mullins and Dana Murray, USA, 7 minutes Revolting Rhymes – Jakob Schuh and Jan Lachauer, UK, 29 minutes Garden Party – Victor Caire and Gabriel Grapperon, France 7 minutes Lost Property Office (additional film) – Daniel Agdag, Australia, 10 minutes Weeds(additional film) – Kevin Hudson, USA,3 minutes Achoo (additional film) – Elise Carret, Camille Lacroix, Charlotte Perroux, Lucas Boutrot, Maoris Creantor, Pierre Hubert, France, 7 minutes

Rating guidelines for each program: Animation – PG. Most of the shorts would be G rated, but the very end of GARDEN PARTY has some disturbing imagery of a human corpse that could be upsetting to younger viewers. Kids eight and over should be fine.

Dear Basketball (director: Glen Keane) Synopsis: Basketball great Kobe Bryant collaborated with visionary animator Glen Keane and legendary composer John Williams on an animated short film that explores what it means to achieve your dream, and then leave it behind. The animated film is an adaptation of Bryant’s NBA retirement announcement after 20 years with the Los Angeles Lakers. Narrated by Bryant, the film’s hand-drawn animation and emotional score will touch fans of all ages with its universal message about love and loss. Director’s Biography: A 38 year veteran of Walt Disney Feature Animation, Glen Keane trained under Walt Disney’s 9 Old Men. Glen Keane went on to create many beloved Disney characters, such as The Little Mermaid, Aladdin, The Beast, Tarzan, and Rapunzel. In 2012, Keane departed Disney to begin Glen Keane Productions as way to further his artistic explorations in animation, design and film.

Dear Basketball Synopsis: Director’s Biography:

Negative Space (directors: Max Porter, Ru Kuwahata) Synopsis: My dad taught me how to pack. Directors’ Biography: Max Porter and Ru Kuwahata are a filmmaking duo based in Baltimore, USA. Collaborating for over a decade as “Tiny Inventions”, they have directed short films, TV commercials, music videos and comics. Produced by Ikki Films and Manuel Cam Studio in France, “NEGATIVE SPACE” is their fourth professional film.

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